Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3315108..3315813 Replicon chromosome
Accession NZ_LR890405
Organism Escherichia coli isolate MSB1_7C-sc-2280317

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag JMW09_RS16010 Protein ID WP_000539521.1
Coordinates 3315108..3315494 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JMW09_RS16015 Protein ID WP_001280945.1
Coordinates 3315484..3315813 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW09_RS15990 3311112..3311738 + 627 WP_001295292.1 glutathione S-transferase GstB -
JMW09_RS15995 3311735..3312850 - 1116 WP_000555038.1 aldose sugar dehydrogenase YliI -
JMW09_RS16000 3312961..3313344 - 384 WP_000497137.1 biofilm formation regulator BssR -
JMW09_RS16005 3313557..3314882 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JMW09_RS16010 3315108..3315494 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW09_RS16015 3315484..3315813 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JMW09_RS16020 3315883..3317211 - 1329 WP_000086879.1 GGDEF domain-containing protein -
JMW09_RS16025 3317219..3319567 - 2349 WP_001322378.1 EAL domain-containing protein -
JMW09_RS16030 3319745..3320656 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T290896 WP_000539521.1 NZ_LR890405:3315108-3315494 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT290896 WP_001280945.1 NZ_LR890405:3315484-3315813 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References