Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2667441..2668079 Replicon chromosome
Accession NZ_LR890405
Organism Escherichia coli isolate MSB1_7C-sc-2280317

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag JMW09_RS12690 Protein ID WP_000813797.1
Coordinates 2667903..2668079 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMW09_RS12685 Protein ID WP_076611057.1
Coordinates 2667441..2667857 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW09_RS12665 2662593..2663534 - 942 WP_001251335.1 ABC transporter permease -
JMW09_RS12670 2663535..2664548 - 1014 WP_000220413.1 ABC transporter ATP-binding protein -
JMW09_RS12675 2664566..2665711 - 1146 WP_000047447.1 ABC transporter substrate-binding protein -
JMW09_RS12680 2665956..2667362 - 1407 WP_000760613.1 PLP-dependent aminotransferase family protein -
JMW09_RS12685 2667441..2667857 - 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMW09_RS12690 2667903..2668079 - 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMW09_RS12695 2668301..2668531 + 231 WP_000494244.1 YncJ family protein -
JMW09_RS12700 2668623..2670584 - 1962 WP_001309488.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMW09_RS12705 2670657..2671193 - 537 WP_000429161.1 DNA-binding transcriptional regulator SutR -
JMW09_RS12710 2671246..2672457 + 1212 WP_001323162.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T290894 WP_000813797.1 NZ_LR890405:c2668079-2667903 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT290894 WP_076611057.1 NZ_LR890405:c2667857-2667441 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References