Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2567706..2569294 Replicon chromosome
Accession NZ_LR890405
Organism Escherichia coli isolate MSB1_7C-sc-2280317

Toxin (Protein)


Gene name hipA Uniprot ID U9YVT8
Locus tag JMW09_RS12245 Protein ID WP_001125415.1
Coordinates 2567972..2569294 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW09_RS12240 Protein ID WP_001296726.1
Coordinates 2567706..2567972 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW09_RS12240 2567706..2567972 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW09_RS12245 2567972..2569294 + 1323 WP_001125415.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
JMW09_RS12250 2569692..2570591 - 900 WP_001057776.1 LysR family transcriptional regulator -
JMW09_RS12255 2570731..2571039 + 309 WP_001221046.1 hypothetical protein -
JMW09_RS12260 2571048..2571737 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
JMW09_RS12265 2571811..2572758 + 948 WP_000854796.1 aldo/keto reductase -
JMW09_RS12270 2572861..2573016 + 156 WP_001322415.1 hypothetical protein -
JMW09_RS12275 2572976..2573395 + 420 WP_001322416.1 amidohydrolase family protein -
JMW09_RS12280 2573346..2573537 + 192 WP_001469139.1 amidohydrolase family protein -
JMW09_RS12285 2573688..2574260 + 573 WP_000789913.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49384.05 Da        Isoelectric Point: 8.5830

>T290892 WP_001125415.1 NZ_LR890405:2567972-2569294 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT290892 WP_001296726.1 NZ_LR890405:2567706-2567972 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YVT8

Antitoxin

Source ID Structure

References