Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1006272..1006926 Replicon chromosome
Accession NZ_LR890405
Organism Escherichia coli isolate MSB1_7C-sc-2280317

Toxin (Protein)


Gene name cptA Uniprot ID B7N7E0
Locus tag JMW09_RS04840 Protein ID WP_000244769.1
Coordinates 1006519..1006926 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JMW09_RS04835 Protein ID WP_000354046.1
Coordinates 1006272..1006538 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW09_RS04815 1002360..1003793 - 1434 WP_001513393.1 6-phospho-beta-glucosidase BglA -
JMW09_RS04820 1003838..1004149 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
JMW09_RS04825 1004313..1004972 + 660 WP_000250274.1 hemolysin III family protein -
JMW09_RS04830 1005049..1006029 - 981 WP_000886049.1 tRNA-modifying protein YgfZ -
JMW09_RS04835 1006272..1006538 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JMW09_RS04840 1006519..1006926 + 408 WP_000244769.1 protein YgfX Toxin
JMW09_RS04845 1006966..1007487 - 522 WP_001055874.1 flavodoxin FldB -
JMW09_RS04850 1007599..1008495 + 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
JMW09_RS04855 1008520..1009230 + 711 WP_000715210.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW09_RS04860 1009236..1010969 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16062.03 Da        Isoelectric Point: 11.5554

>T290886 WP_000244769.1 NZ_LR890405:1006519-1006926 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGK
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT290886 WP_000354046.1 NZ_LR890405:1006272-1006538 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J3T1

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References