Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5215858..5216483 Replicon chromosome
Accession NZ_LR890395
Organism Klebsiella pneumoniae isolate INF044-sc-2279940

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JMW67_RS25670 Protein ID WP_002882817.1
Coordinates 5215858..5216241 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMW67_RS25675 Protein ID WP_004150355.1
Coordinates 5216241..5216483 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW67_RS25655 5213224..5214126 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMW67_RS25660 5214123..5214758 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMW67_RS25665 5214755..5215684 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMW67_RS25670 5215858..5216241 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JMW67_RS25675 5216241..5216483 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMW67_RS25680 5216688..5217605 + 918 WP_002882812.1 alpha/beta hydrolase -
JMW67_RS25685 5217619..5218560 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMW67_RS25690 5218605..5219042 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMW67_RS25695 5219039..5219899 - 861 WP_002882807.1 virulence factor BrkB family protein -
JMW67_RS25700 5219893..5220492 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T290878 WP_002882817.1 NZ_LR890395:c5216241-5215858 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT290878 WP_004150355.1 NZ_LR890395:c5216483-5216241 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References