Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4019532..4020151 Replicon chromosome
Accession NZ_LR890395
Organism Klebsiella pneumoniae isolate INF044-sc-2279940

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JMW67_RS19935 Protein ID WP_002892050.1
Coordinates 4019933..4020151 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JMW67_RS19930 Protein ID WP_002892066.1
Coordinates 4019532..4019906 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW67_RS19920 4014684..4015877 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMW67_RS19925 4015900..4019046 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JMW67_RS19930 4019532..4019906 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JMW67_RS19935 4019933..4020151 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JMW67_RS19940 4020310..4020876 + 567 WP_002892030.1 maltose O-acetyltransferase -
JMW67_RS19945 4020848..4020988 - 141 WP_004147370.1 hypothetical protein -
JMW67_RS19950 4021009..4021479 + 471 WP_002892026.1 YlaC family protein -
JMW67_RS19955 4021454..4022905 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JMW67_RS19960 4023006..4023704 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
JMW67_RS19965 4023701..4023841 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JMW67_RS19970 4023841..4024104 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290874 WP_002892050.1 NZ_LR890395:4019933-4020151 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT290874 WP_002892066.1 NZ_LR890395:4019532-4019906 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References