Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2610954..2612542 Replicon chromosome
Accession NZ_LR890395
Organism Klebsiella pneumoniae isolate INF044-sc-2279940

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag JMW67_RS12925 Protein ID WP_004199851.1
Coordinates 2610954..2612276 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW67_RS12930 Protein ID WP_002904790.1
Coordinates 2612276..2612542 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW67_RS12910 2606019..2608520 + 2502 WP_004199853.1 fimbrial biogenesis outer membrane usher protein -
JMW67_RS12915 2608508..2609512 + 1005 WP_004199852.1 type 1 fimbrial protein -
JMW67_RS12920 2609645..2610937 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW67_RS12925 2610954..2612276 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW67_RS12930 2612276..2612542 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW67_RS12935 2612808..2613134 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMW67_RS12940 2613131..2613631 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW67_RS12945 2613609..2614988 - 1380 WP_004199850.1 purine permease -
JMW67_RS12950 2615334..2616488 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW67_RS12955 2616469..2617392 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T290873 WP_004199851.1 NZ_LR890395:c2612276-2610954 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT290873 WP_002904790.1 NZ_LR890395:c2612542-2612276 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References