Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5150911..5151536 Replicon chromosome
Accession NZ_LR890391
Organism Klebsiella pneumoniae isolate KSB2_2C-sc-2280354

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMW68_RS24865 Protein ID WP_021312635.1
Coordinates 5150911..5151294 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMW68_RS24870 Protein ID WP_004150355.1
Coordinates 5151294..5151536 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW68_RS24850 5148277..5149179 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMW68_RS24855 5149176..5149811 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMW68_RS24860 5149808..5150737 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMW68_RS24865 5150911..5151294 - 384 WP_021312635.1 type II toxin-antitoxin system VapC family toxin Toxin
JMW68_RS24870 5151294..5151536 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMW68_RS24875 5151741..5152658 + 918 WP_004178029.1 alpha/beta hydrolase -
JMW68_RS24880 5152672..5153613 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMW68_RS24885 5153658..5154095 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMW68_RS24890 5154092..5154952 - 861 WP_004146232.1 virulence factor BrkB family protein -
JMW68_RS24895 5154946..5155545 - 600 WP_040148118.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14349.56 Da        Isoelectric Point: 7.3178

>T290863 WP_021312635.1 NZ_LR890391:c5151294-5150911 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVATPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT290863 WP_004150355.1 NZ_LR890391:c5151536-5151294 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References