Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4831558..4833239 Replicon chromosome
Accession NZ_LR890384
Organism Klebsiella pneumoniae isolate INF333

Toxin (Protein)


Gene name mosT Uniprot ID A0A486LFH0
Locus tag JMW24_RS23365 Protein ID WP_023328808.1
Coordinates 4831558..4832475 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag JMW24_RS23370 Protein ID WP_004177809.1
Coordinates 4832481..4833239 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW24_RS23345 4826939..4828459 + 1521 WP_040147141.1 sugar ABC transporter ATP-binding protein -
JMW24_RS23350 4828456..4829454 + 999 WP_031592479.1 ribose ABC transporter permease -
JMW24_RS23355 4829485..4830426 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
JMW24_RS23360 4830501..4831433 + 933 WP_040147145.1 carbohydrate kinase family protein -
JMW24_RS23365 4831558..4832475 - 918 WP_023328808.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JMW24_RS23370 4832481..4833239 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
JMW24_RS23375 4833325..4834053 - 729 WP_002885152.1 response regulator transcription factor -
JMW24_RS23380 4834326..4836473 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
JMW24_RS23385 4836703..4837389 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34660.13 Da        Isoelectric Point: 5.4707

>T290847 WP_023328808.1 NZ_LR890384:c4832475-4831558 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT290847 WP_004177809.1 NZ_LR890384:c4833239-4832481 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFH0

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References