Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2604860..2606448 Replicon chromosome
Accession NZ_LR890384
Organism Klebsiella pneumoniae isolate INF333

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMW24_RS12685 Protein ID WP_040148030.1
Coordinates 2604860..2606182 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW24_RS12690 Protein ID WP_002904790.1
Coordinates 2606182..2606448 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW24_RS12670 2599916..2602417 + 2502 WP_201506343.1 fimbrial biogenesis outer membrane usher protein -
JMW24_RS12675 2602405..2603409 + 1005 WP_040148029.1 type 1 fimbrial protein -
JMW24_RS12680 2603551..2604843 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW24_RS12685 2604860..2606182 - 1323 WP_040148030.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW24_RS12690 2606182..2606448 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW24_RS12695 2606713..2607039 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMW24_RS12700 2607036..2607536 - 501 WP_040148032.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW24_RS12705 2607514..2608893 - 1380 WP_099745200.1 purine permease -
JMW24_RS12710 2609239..2610393 + 1155 WP_040148035.1 FAD-dependent urate hydroxylase HpxO -
JMW24_RS12715 2610374..2611297 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5366

>T290843 WP_040148030.1 NZ_LR890384:c2606182-2604860 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT290843 WP_002904790.1 NZ_LR890384:c2606448-2606182 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References