Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4106687..4107393 Replicon chromosome
Accession NZ_LR890360
Organism Klebsiella pneumoniae isolate INF049-sc-2279950

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag JMW75_RS20215 Protein ID WP_117037546.1
Coordinates 4107025..4107393 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A485WAM6
Locus tag JMW75_RS20210 Protein ID WP_023302278.1
Coordinates 4106687..4107004 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW75_RS20165 4101828..4102652 + 825 WP_023302271.1 DUF945 domain-containing protein -
JMW75_RS20170 4102861..4103571 + 711 WP_023302272.1 DeoR family transcriptional regulator -
JMW75_RS20175 4103597..4104133 + 537 WP_023302273.1 DUF4339 domain-containing protein -
JMW75_RS20180 4104175..4104612 + 438 WP_023301392.1 hypothetical protein -
JMW75_RS20185 4104679..4105089 + 411 WP_201519709.1 hypothetical protein -
JMW75_RS20190 4105167..4105403 + 237 WP_032410024.1 DUF905 domain-containing protein -
JMW75_RS20195 4105490..4105948 + 459 WP_023302275.1 antirestriction protein -
JMW75_RS20200 4105957..4106439 + 483 WP_023302276.1 RadC family protein -
JMW75_RS20205 4106448..4106669 + 222 WP_023302277.1 DUF987 domain-containing protein -
JMW75_RS20210 4106687..4107004 + 318 WP_023302278.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMW75_RS20215 4107025..4107393 + 369 WP_117037546.1 TA system toxin CbtA family protein Toxin
JMW75_RS20220 4107390..4107731 + 342 WP_024622904.1 hypothetical protein -
JMW75_RS20225 4107854..4110499 - 2646 WP_024622905.1 LuxR family transcriptional regulator -
JMW75_RS20230 4110873..4111832 + 960 WP_023302280.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-104)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13669.85 Da        Isoelectric Point: 7.2897

>T290771 WP_117037546.1 NZ_LR890360:4107025-4107393 [Klebsiella pneumoniae]
MKNLPATISQAAKPCMSPVAVWQMLLTHLLEQHYGLMLSDTPFSDEAVIQEHIDAGITLANAVNFLVEKYELVRIDRCGF
SSQVQAPYLTATDILHARKACGLMSRYSYREVSNIVLSRSRI

Download         Length: 369 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11860.67 Da        Isoelectric Point: 6.4629

>AT290771 WP_023302278.1 NZ_LR890360:4106687-4107004 [Klebsiella pneumoniae]
MSNPTWGLLRDITPCLGARLVQEGNRLYYLVDRASITGKFSDAEILKLDVVFPHFISQMESMLTIGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYLTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A485WAM6

References