Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 790100..790757 Replicon chromosome
Accession NZ_LR890360
Organism Klebsiella pneumoniae isolate INF049-sc-2279950

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMW75_RS03935 Protein ID WP_002916310.1
Coordinates 790347..790757 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMW75_RS03930 Protein ID WP_002916312.1
Coordinates 790100..790366 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW75_RS03905 785256..786689 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JMW75_RS03910 786808..787536 - 729 WP_023342613.1 MurR/RpiR family transcriptional regulator -
JMW75_RS03915 787586..787897 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMW75_RS03920 788061..788720 + 660 WP_002916317.1 hemolysin III family protein -
JMW75_RS03925 788871..789854 - 984 WP_023342614.1 tRNA-modifying protein YgfZ -
JMW75_RS03930 790100..790366 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMW75_RS03935 790347..790757 + 411 WP_002916310.1 protein YgfX Toxin
JMW75_RS03940 790764..791285 - 522 WP_002916308.1 flavodoxin FldB -
JMW75_RS03945 791386..792282 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMW75_RS03950 792305..793018 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW75_RS03955 793024..794757 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T290764 WP_002916310.1 NZ_LR890360:790347-790757 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT290764 WP_002916312.1 NZ_LR890360:790100-790366 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References