Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 837700..838177 Replicon chromosome
Accession NC_020533
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAI4T8_RS04030 Protein ID WP_000052076.1
Coordinates 837700..837888 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAI4T8_RS04035 Protein ID WP_001059690.1
Coordinates 837917..838177 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAI4T8_RS04000 833694..834215 + 522 WP_000824485.1 hypothetical protein -
SAI4T8_RS04005 834556..835242 + 687 WP_000141557.1 thermonuclease family protein -
SAI4T8_RS04010 835599..835799 + 201 WP_001059082.1 cold-shock protein -
SAI4T8_RS04015 836291..836509 - 219 WP_000005886.1 hypothetical protein -
SAI4T8_RS04020 836571..836855 - 285 WP_001004399.1 hypothetical protein -
SAI4T8_RS04025 836943..837512 - 570 WP_001106654.1 hypothetical protein -
SAI4T8_RS04030 837700..837888 - 189 WP_000052076.1 hypothetical protein Toxin
SAI4T8_RS04035 837917..838177 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAI4T8_RS04040 838518..838721 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAI4T8_RS04045 838718..838954 - 237 WP_000349581.1 hypothetical protein -
SAI4T8_RS04050 839179..839760 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAI4T8_RS04055 839833..840450 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SAI4T8_RS04060 840605..841099 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAI4T8_RS04065 841498..841920 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAI4T8_RS04070 842068..842784 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T29076 WP_000052076.1 NC_020533:c837888-837700 [Staphylococcus aureus subsp. aureus ST228]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T29076 NC_020533:c837888-837700 [Staphylococcus aureus subsp. aureus ST228]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT29076 WP_001059690.1 NC_020533:c838177-837917 [Staphylococcus aureus subsp. aureus ST228]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT29076 NC_020533:c838177-837917 [Staphylococcus aureus subsp. aureus ST228]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References