Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 77442..78178 Replicon plasmid 2
Accession NZ_LR890357
Organism Klebsiella pneumoniae isolate INF231-sc-2280121

Toxin (Protein)


Gene name tacT Uniprot ID A0A142I508
Locus tag JMV88_RS26585 Protein ID WP_032720647.1
Coordinates 77442..77924 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMV88_RS26590 Protein ID WP_003026799.1
Coordinates 77912..78178 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV88_RS26570 73072..74004 - 933 WP_038992638.1 hypothetical protein -
JMV88_RS26575 74001..75017 - 1017 WP_042938210.1 hypothetical protein -
JMV88_RS26580 75300..77012 + 1713 WP_038992633.1 ROK family protein -
JMV88_RS26585 77442..77924 - 483 WP_032720647.1 GNAT family N-acetyltransferase Toxin
JMV88_RS26590 77912..78178 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMV88_RS26595 78459..79061 + 603 Protein_76 transposase -
JMV88_RS26600 79388..79940 + 553 Protein_77 DUF4113 domain-containing protein -
JMV88_RS26605 80118..80441 + 324 WP_032720638.1 type II toxin-antitoxin system RelE/ParE family toxin -
JMV88_RS26610 80490..80792 + 303 WP_032720637.1 helix-turn-helix domain-containing protein -
JMV88_RS26615 80835..81002 - 168 WP_153591440.1 hypothetical protein -
JMV88_RS26620 81190..81369 - 180 WP_032720701.1 hypothetical protein -
JMV88_RS26625 81393..81776 - 384 WP_032720636.1 hypothetical protein -
JMV88_RS26630 81881..82453 - 573 WP_032720635.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..195539 195539
- flank IS/Tn - - 78672..79061 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.02 Da        Isoelectric Point: 9.8720

>T290759 WP_032720647.1 NZ_LR890357:c77924-77442 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT290759 WP_003026799.1 NZ_LR890357:c78178-77912 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142I508

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References