Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 3941594..3942273 Replicon chromosome
Accession NZ_LR890349
Organism Escherichia coli isolate MSB1_9D-sc-2280338

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag JMW03_RS19225 Protein ID WP_016246873.1
Coordinates 3941932..3942273 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID -
Locus tag JMW03_RS19220 Protein ID WP_016246874.1
Coordinates 3941594..3941911 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW03_RS19175 3937032..3937853 + 822 WP_016246877.1 DUF945 domain-containing protein -
JMW03_RS19180 3938070..3938771 + 702 WP_137474786.1 WYL domain-containing protein -
JMW03_RS19185 3938812..3939048 + 237 WP_001144031.1 hypothetical protein -
JMW03_RS19190 3939048..3939491 + 444 WP_001547764.1 phage transcriptional regulator -
JMW03_RS19195 3939514..3939981 + 468 WP_001547765.1 hypothetical protein -
JMW03_RS19200 3940058..3940297 + 240 WP_000194654.1 DUF905 domain-containing protein -
JMW03_RS19205 3940395..3940853 + 459 WP_000211838.1 antirestriction protein -
JMW03_RS19210 3940869..3941345 + 477 WP_000811693.1 RadC family protein -
JMW03_RS19215 3941354..3941575 + 222 WP_016246875.1 DUF987 domain-containing protein -
JMW03_RS19220 3941594..3941911 + 318 WP_016246874.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMW03_RS19225 3941932..3942273 + 342 WP_016246873.1 TA system toxin CbtA family protein Toxin
JMW03_RS19235 3942845..3944098 - 1254 WP_201514041.1 glutamate-5-semialdehyde dehydrogenase -
JMW03_RS19240 3944110..3945213 - 1104 WP_001285288.1 glutamate 5-kinase -
JMW03_RS19245 3945501..3946556 + 1056 WP_000749881.1 phosphoporin PhoE -
JMW03_RS19250 3946595..3946996 - 402 WP_000174677.1 sigma factor-binding protein Crl -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR 3934158..3970884 36726


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12987.05 Da        Isoelectric Point: 10.2764

>T290743 WP_016246873.1 NZ_LR890349:3941932-3942273 [Escherichia coli]
MKTLPATTQRAAKPCLAPVAVWQMLLTRLLKQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11831.42 Da        Isoelectric Point: 7.0169

>AT290743 WP_016246874.1 NZ_LR890349:3941594-3941911 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETCPHFIRHMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQS

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References