Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3709249..3709867 Replicon chromosome
Accession NZ_LR890349
Organism Escherichia coli isolate MSB1_9D-sc-2280338

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JMW03_RS18125 Protein ID WP_001291435.1
Coordinates 3709649..3709867 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JMW03_RS18120 Protein ID WP_000344800.1
Coordinates 3709249..3709623 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW03_RS18110 3704338..3705531 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMW03_RS18115 3705554..3708703 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JMW03_RS18120 3709249..3709623 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JMW03_RS18125 3709649..3709867 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JMW03_RS18130 3710038..3710589 + 552 WP_000102564.1 maltose O-acetyltransferase -
JMW03_RS18135 3710705..3711175 + 471 WP_000136192.1 YlaC family protein -
JMW03_RS18140 3711339..3712889 + 1551 WP_001514985.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JMW03_RS18145 3712931..3713284 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JMW03_RS18155 3713663..3713974 + 312 WP_000409911.1 MGMT family protein -
JMW03_RS18160 3714005..3714577 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290742 WP_001291435.1 NZ_LR890349:3709649-3709867 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT290742 WP_000344800.1 NZ_LR890349:3709249-3709623 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References