Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 935339..935993 Replicon chromosome
Accession NZ_LR890349
Organism Escherichia coli isolate MSB1_9D-sc-2280338

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag JMW03_RS04500 Protein ID WP_000244777.1
Coordinates 935586..935993 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JMW03_RS04495 Protein ID WP_000354046.1
Coordinates 935339..935605 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW03_RS04475 931308..932741 - 1434 WP_001514525.1 6-phospho-beta-glucosidase BglA -
JMW03_RS04480 932786..933097 + 312 WP_001514524.1 N(4)-acetylcytidine aminohydrolase -
JMW03_RS04485 933261..933920 + 660 WP_160322130.1 hemolysin III family protein -
JMW03_RS04490 934116..935096 - 981 WP_001514522.1 tRNA-modifying protein YgfZ -
JMW03_RS04495 935339..935605 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JMW03_RS04500 935586..935993 + 408 WP_000244777.1 toxin CptA Toxin
JMW03_RS04505 936033..936554 - 522 WP_001055874.1 flavodoxin FldB -
JMW03_RS04510 936666..937562 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JMW03_RS04515 937587..938297 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW03_RS04520 938303..940036 + 1734 WP_073464323.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T290735 WP_000244777.1 NZ_LR890349:935586-935993 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT290735 WP_000354046.1 NZ_LR890349:935339-935605 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References