Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3906897..3907522 Replicon chromosome
Accession NZ_LR890343
Organism Klebsiella pneumoniae isolate KSB2_2B-sc-2280339

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMW06_RS18755 Protein ID WP_021312635.1
Coordinates 3906897..3907280 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMW06_RS18760 Protein ID WP_004150355.1
Coordinates 3907280..3907522 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW06_RS18740 3904263..3905165 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMW06_RS18745 3905162..3905797 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMW06_RS18750 3905794..3906723 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMW06_RS18755 3906897..3907280 - 384 WP_021312635.1 type II toxin-antitoxin system VapC family toxin Toxin
JMW06_RS18760 3907280..3907522 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMW06_RS18765 3907727..3908644 + 918 WP_004178029.1 alpha/beta hydrolase -
JMW06_RS18770 3908658..3909598 - 941 Protein_3666 fatty acid biosynthesis protein FabY -
JMW06_RS18775 3909643..3910080 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMW06_RS18780 3910077..3910937 - 861 WP_004146232.1 virulence factor BrkB family protein -
JMW06_RS18785 3910931..3911530 - 600 WP_040148118.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14349.56 Da        Isoelectric Point: 7.3178

>T290726 WP_021312635.1 NZ_LR890343:c3907280-3906897 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVATPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT290726 WP_004150355.1 NZ_LR890343:c3907522-3907280 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References