Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1361299..1362887 Replicon chromosome
Accession NZ_LR890343
Organism Klebsiella pneumoniae isolate KSB2_2B-sc-2280339

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMW06_RS06585 Protein ID WP_040148030.1
Coordinates 1361299..1362621 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW06_RS06590 Protein ID WP_002904790.1
Coordinates 1362621..1362887 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW06_RS06570 1356355..1358856 + 2502 WP_201506343.1 fimbrial biogenesis outer membrane usher protein -
JMW06_RS06575 1358844..1359848 + 1005 WP_040148029.1 type 1 fimbrial protein -
JMW06_RS06580 1359990..1361282 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW06_RS06585 1361299..1362621 - 1323 WP_040148030.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW06_RS06590 1362621..1362887 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW06_RS06595 1363152..1363478 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMW06_RS06600 1363475..1363975 - 501 WP_040148032.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW06_RS06605 1363953..1365332 - 1380 WP_099745200.1 purine permease -
JMW06_RS06610 1365678..1366832 + 1155 WP_040148035.1 FAD-dependent urate hydroxylase HpxO -
JMW06_RS06615 1366813..1367736 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5366

>T290721 WP_040148030.1 NZ_LR890343:c1362621-1361299 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT290721 WP_002904790.1 NZ_LR890343:c1362887-1362621 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References