290699

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4175990..4176540 Replicon chromosome
Accession NZ_LR890334
Organism Escherichia coli isolate MINF_9A-sc-2280436

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag JMW07_RS20090 Protein ID WP_001160966.1
Coordinates 4176226..4176540 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1NMQ0
Locus tag JMW07_RS20085 Protein ID WP_000125568.1
Coordinates 4175990..4176223 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW07_RS20060 4171064..4171351 + 288 WP_000203741.1 ferredoxin-like protein FixX -
JMW07_RS20065 4171409..4172740 + 1332 WP_001183201.1 MFS transporter -
JMW07_RS20070 4172848..4173378 + 531 WP_000600732.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
JMW07_RS20075 4173371..4175233 + 1863 WP_022645165.1 glutathione-regulated potassium-efflux system protein KefC -
JMW07_RS20080 4175425..4175904 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
JMW07_RS20085 4175990..4176223 + 234 WP_000125568.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JMW07_RS20090 4176226..4176540 + 315 WP_001160966.1 CcdB family protein Toxin
JMW07_RS20095 4176537..4177385 - 849 WP_201519828.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
JMW07_RS20100 4177392..4177769 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
JMW07_RS20105 4177772..4178593 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
JMW07_RS20110 4178590..4179579 - 990 WP_000241224.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
JMW07_RS20115 4179579..4180865 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T290699 WP_001160966.1 NZ_LR890334:4176226-4176540 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8560.55 Da        Isoelectric Point: 5.8062

>AT290699 WP_000125568.1 NZ_LR890334:4175990-4176223 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A829GEF2

References