290698

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4067358..4067934 Replicon chromosome
Accession NZ_LR890334
Organism Escherichia coli isolate MINF_9A-sc-2280436

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag JMW07_RS19560 Protein ID WP_001297643.1
Coordinates 4067358..4067645 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag JMW07_RS19565 Protein ID WP_000063156.1
Coordinates 4067632..4067934 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW07_RS19540 4063611..4064891 - 1281 WP_001037400.1 DUF445 domain-containing protein -
JMW07_RS19545 4064932..4066164 - 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
JMW07_RS19550 4066310..4066405 - 96 Protein_3818 dienelactone hydrolase family protein -
JMW07_RS19555 4066462..4067159 + 698 Protein_3819 IS1 family transposase -
JMW07_RS19560 4067358..4067645 + 288 WP_001297643.1 BrnT family toxin Toxin
JMW07_RS19565 4067632..4067934 + 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
JMW07_RS19570 4067968..4068924 - 957 WP_001297640.1 GTPase -
JMW07_RS19575 4068935..4069138 - 204 WP_000467859.1 YbdD/YjiX family protein -
JMW07_RS19580 4069188..4071338 - 2151 WP_001295524.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T290698 WP_001297643.1 NZ_LR890334:4067358-4067645 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT290698 WP_000063156.1 NZ_LR890334:4067632-4067934 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References