290694

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 3718484..3719472 Replicon chromosome
Accession NZ_LR890334
Organism Escherichia coli isolate MINF_9A-sc-2280436

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag JMW07_RS17780 Protein ID WP_014640052.1
Coordinates 3719086..3719472 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0J5Z6D5
Locus tag JMW07_RS17775 Protein ID WP_000458584.1
Coordinates 3718484..3719056 (+) Length 191 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW07_RS17745 3713554..3714162 + 609 WP_000646078.1 transcriptional repressor LexA -
JMW07_RS17750 3714235..3715560 + 1326 WP_001361471.1 MATE family efflux transporter DinF -
JMW07_RS17755 3715676..3715885 + 210 WP_001296638.1 CsbD family protein -
JMW07_RS17760 3715927..3716442 - 516 WP_000416263.1 zinc uptake transcriptional repressor Zur -
JMW07_RS17765 3716760..3717764 + 1005 WP_022646425.1 DUF2713 family protein -
JMW07_RS17770 3718126..3718248 + 123 WP_001300034.1 hypothetical protein -
JMW07_RS17775 3718484..3719056 + 573 WP_000458584.1 SocA family protein Antitoxin
JMW07_RS17780 3719086..3719472 + 387 WP_014640052.1 hypothetical protein Toxin
JMW07_RS17785 3719512..3719685 + 174 WP_000390072.1 hypothetical protein -
JMW07_RS17790 3719733..3720014 - 282 WP_001093916.1 pyocin activator PrtN family protein -
JMW07_RS17795 3720051..3720623 - 573 WP_001061348.1 3'-5' exoribonuclease -
JMW07_RS17800 3720623..3721453 - 831 WP_201519818.1 hypothetical protein -
JMW07_RS17805 3721453..3721815 - 363 WP_001565177.1 phage protein -
JMW07_RS17810 3721806..3722342 - 537 WP_000008200.1 5'-deoxynucleotidase -
JMW07_RS17815 3722470..3723294 - 825 WP_089438609.1 DUF2303 family protein -
JMW07_RS17820 3723360..3723722 - 363 WP_000135682.1 hypothetical protein -
JMW07_RS17825 3723737..3724047 - 311 Protein_3478 hypothetical protein -
JMW07_RS17830 3724160..3724405 + 246 WP_000141753.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3713554..3760264 46710


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-137)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T290694 WP_014640052.1 NZ_LR890334:3719086-3719472 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21973.21 Da        Isoelectric Point: 6.0283

>AT290694 WP_000458584.1 NZ_LR890334:3718484-3719056 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J5Z6D5

References