290692

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3116285..3116897 Replicon chromosome
Accession NZ_LR890334
Organism Escherichia coli isolate MINF_9A-sc-2280436

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag JMW07_RS15035 Protein ID WP_000833473.1
Coordinates 3116712..3116897 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0A1AGA0
Locus tag JMW07_RS15030 Protein ID WP_022646255.1
Coordinates 3116285..3116695 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW07_RS15015 3111742..3112557 - 816 WP_022646253.1 AraC family transcriptional regulator -
JMW07_RS15020 3112783..3114183 + 1401 WP_001600688.1 MFS transporter -
JMW07_RS15025 3114194..3116173 + 1980 WP_022646254.1 glycoside hydrolase family 127 protein -
JMW07_RS15030 3116285..3116695 - 411 WP_022646255.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMW07_RS15035 3116712..3116897 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
JMW07_RS15040 3117370..3118449 + 1080 WP_000061477.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
JMW07_RS15045 3118490..3120028 - 1539 WP_000183976.1 aldehyde dehydrogenase AldB -
JMW07_RS15050 3120136..3121431 - 1296 WP_000985736.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T290692 WP_000833473.1 NZ_LR890334:c3116897-3116712 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15214.08 Da        Isoelectric Point: 4.4482

>AT290692 WP_022646255.1 NZ_LR890334:c3116695-3116285 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALAAHFETLCEMDEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AGA0

References