290683

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 601762..602400 Replicon chromosome
Accession NZ_LR890334
Organism Escherichia coli isolate MINF_9A-sc-2280436

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JMW07_RS03015 Protein ID WP_000813794.1
Coordinates 601762..601938 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMW07_RS03020 Protein ID WP_001270286.1
Coordinates 601984..602400 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW07_RS02995 597384..598595 - 1212 WP_071788120.1 BenE family transporter YdcO -
JMW07_RS03000 598648..599184 + 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
JMW07_RS03005 599257..601218 + 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMW07_RS03010 601310..601540 - 231 WP_000491567.1 DUF2554 family protein -
JMW07_RS03015 601762..601938 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMW07_RS03020 601984..602400 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMW07_RS03025 602479..603885 + 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
JMW07_RS03030 604130..605275 + 1146 WP_000047466.1 ABC transporter substrate-binding protein -
JMW07_RS03035 605293..606306 + 1014 WP_022645666.1 ABC transporter ATP-binding protein -
JMW07_RS03040 606307..607248 + 942 WP_022645667.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T290683 WP_000813794.1 NZ_LR890334:601762-601938 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT290683 WP_001270286.1 NZ_LR890334:601984-602400 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References