Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2071563..2072092 Replicon chromosome
Accession NC_020532
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SAI3T3_RS10390 Protein ID WP_000621175.1
Coordinates 2071563..2071925 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag SAI3T3_RS10395 Protein ID WP_000948331.1
Coordinates 2071922..2072092 (-) Length 57 a.a.

Genomic Context

SAI3T3_RS10365SAI3T3_RS10370SAI3T3_RS10375SAI3T3_RS10380SAI3T3_RS10390SAI3T3_RS10395SAI3T3_RS10400SAI3T3_RS10405SAI3T3_RS10410SAI3T3_RS10415SAI3T3_RS10420SAI3T3_RS10425
Location: 2068541..2069311 (771 bp)
Type: Others
Protein ID: WP_001041111.1
Location: 2069286..2069765 (480 bp)
Type: Others
Protein ID: WP_001190829.1
Location: 2069767..2070093 (327 bp)
Type: Others
Protein ID: WP_001052491.1
Location: 2070212..2071213 (1002 bp)
Type: Others
Protein ID: WP_000390829.1
Location: 2071563..2071925 (363 bp)
Type: Toxin
Protein ID: WP_000621175.1
Location: 2071922..2072092 (171 bp)
Type: Antitoxin
Protein ID: WP_000948331.1
Location: 2072177..2073325 (1149 bp)
Type: Others
Protein ID: WP_001281154.1
Location: 2073391..2073750 (360 bp)
Type: Others
Protein ID: WP_000581197.1
Location: 2073754..2074245 (492 bp)
Type: Others
Protein ID: WP_001205912.1
Location: 2074232..2075815 (1584 bp)
Type: Others
Protein ID: WP_001294626.1
Location: 2075808..2076287 (480 bp)
Type: Others
Protein ID: WP_001287087.1
Location: 2076495..2077055 (561 bp)
Type: Others
Protein ID: WP_001092411.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SAI3T3_RS103652068541..2069311-771WP_001041111.1RNA polymerase sigma factor SigB-
SAI3T3_RS103702069286..2069765-480WP_001190829.1anti-sigma B factor RsbW-
SAI3T3_RS103752069767..2070093-327WP_001052491.1anti-sigma factor antagonist-
SAI3T3_RS103802070212..2071213-1002WP_000390829.1PP2C family protein-serine/threonine phosphatase-
SAI3T3_RS103902071563..2071925-363WP_000621175.1type II toxin-antitoxin system PemK/MazF family toxinToxin
SAI3T3_RS103952071922..2072092-171WP_000948331.1type II toxin-antitoxin system antitoxin MazEAntitoxin
SAI3T3_RS104002072177..2073325-1149WP_001281154.1alanine racemase-
SAI3T3_RS104052073391..2073750-360WP_000581197.1holo-ACP synthase-
SAI3T3_RS104102073754..2074245-492WP_001205912.1PH domain-containing protein-
SAI3T3_RS104152074232..2075815-1584WP_001294626.1PH domain-containing protein-
SAI3T3_RS104202075808..2076287-480WP_001287087.1hypothetical protein-
SAI3T3_RS104252076495..2077055-561WP_001092411.1K(+)-transporting ATPase subunit C-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T29068 WP_000621175.1 NC_020532:c2071925-2071563 [Staphylococcus aureus subsp. aureus ST228]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T29068 NC_020532:c2071925-2071563 [Staphylococcus aureus subsp. aureus ST228]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT29068 WP_000948331.1 NC_020532:c2072092-2071922 [Staphylococcus aureus subsp. aureus ST228]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT29068 NC_020532:c2072092-2071922 [Staphylococcus aureus subsp. aureus ST228]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E0VRZ1

References