Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4614960..4615603 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JMV91_RS22535 Protein ID WP_049038273.1
Coordinates 4615316..4615603 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag JMV91_RS22530 Protein ID WP_000593555.1
Coordinates 4614960..4615319 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS22500 4610075..4610548 + 474 WP_012311717.1 PTS sugar transporter subunit IIA -
JMV91_RS22505 4610545..4610826 + 282 WP_000084021.1 PTS sugar transporter subunit IIB -
JMV91_RS22510 4610900..4612258 + 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
JMV91_RS22515 4612251..4613759 + 1509 WP_012311797.1 carbohydrate kinase -
JMV91_RS22520 4613749..4614018 + 270 WP_000949581.1 HPr family phosphocarrier protein -
JMV91_RS22525 4614050..4614910 + 861 WP_001131792.1 class II aldolase -
JMV91_RS22530 4614960..4615319 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMV91_RS22535 4615316..4615603 - 288 WP_049038273.1 type II toxin-antitoxin system HicA family toxin Toxin
JMV91_RS22540 4615663..4616787 - 1125 WP_001314210.1 ABC transporter permease -
JMV91_RS22545 4616787..4619522 - 2736 WP_000149118.1 ribosome-associated ATPase/putative transporter RbbA -
JMV91_RS22550 4619519..4620586 - 1068 WP_000361481.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(34-84)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10490.98 Da        Isoelectric Point: 7.7845

>T290667 WP_049038273.1 NZ_LR890326:c4615603-4615316 [Escherichia coli]
IRTCHENPGTGFTEETKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGA
VESVRDWLLSIGVKP

Download         Length: 288 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT290667 WP_000593555.1 NZ_LR890326:c4615319-4614960 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References