Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3928716..3929370 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag JMV91_RS19090 Protein ID WP_000244772.1
Coordinates 3928716..3929123 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JMV91_RS19095 Protein ID WP_000354046.1
Coordinates 3929104..3929370 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS19070 3924673..3926406 - 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -
JMV91_RS19075 3926412..3927122 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMV91_RS19080 3927147..3928043 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JMV91_RS19085 3928155..3928676 + 522 WP_001055874.1 flavodoxin FldB -
JMV91_RS19090 3928716..3929123 - 408 WP_000244772.1 protein YgfX Toxin
JMV91_RS19095 3929104..3929370 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JMV91_RS19100 3929613..3930593 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
JMV91_RS19105 3930670..3931329 - 660 WP_000250274.1 hemolysin III family protein -
JMV91_RS19110 3931493..3931804 - 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
JMV91_RS19115 3931849..3933282 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
JMV91_RS19120 3933339..3934082 - 744 WP_075591686.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T290664 WP_000244772.1 NZ_LR890326:c3929123-3928716 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT290664 WP_000354046.1 NZ_LR890326:c3929370-3929104 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References