Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2825837..2826621 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag JMV91_RS13865 Protein ID WP_000613626.1
Coordinates 2826127..2826621 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B1LI61
Locus tag JMV91_RS13860 Protein ID WP_001110446.1
Coordinates 2825837..2826130 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS13850 2820998..2821957 - 960 WP_000846337.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
JMV91_RS13855 2822530..2825703 + 3174 WP_075591672.1 ribonuclease E -
JMV91_RS13860 2825837..2826130 + 294 WP_001110446.1 DUF1778 domain-containing protein Antitoxin
JMV91_RS13865 2826127..2826621 + 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
JMV91_RS13870 2826716..2827669 - 954 WP_001212763.1 flagellar hook-associated protein FlgL -
JMV91_RS13875 2827681..2829324 - 1644 WP_000096448.1 flagellar hook-associated protein FlgK -
JMV91_RS13880 2829390..2830331 - 942 WP_012311956.1 flagellar assembly peptidoglycan hydrolase FlgJ -
JMV91_RS13885 2830331..2831428 - 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T290662 WP_000613626.1 NZ_LR890326:2826127-2826621 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11079.67 Da        Isoelectric Point: 10.5423

>AT290662 WP_001110446.1 NZ_LR890326:2825837-2826130 [Escherichia coli]
MPAANNIPARRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G775

References