Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2460446..2461084 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JMV91_RS12020 Protein ID WP_000813794.1
Coordinates 2460908..2461084 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMV91_RS12015 Protein ID WP_001270286.1
Coordinates 2460446..2460862 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS11995 2455598..2456539 - 942 WP_001251303.1 ABC transporter permease -
JMV91_RS12000 2456540..2457553 - 1014 WP_000220391.1 ABC transporter ATP-binding protein -
JMV91_RS12005 2457571..2458716 - 1146 WP_000034364.1 ABC transporter substrate-binding protein -
JMV91_RS12010 2458961..2460367 - 1407 WP_000760611.1 PLP-dependent aminotransferase family protein -
JMV91_RS12015 2460446..2460862 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMV91_RS12020 2460908..2461084 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMV91_RS12025 2461306..2461536 + 231 WP_000491567.1 DUF2554 family protein -
JMV91_RS12030 2461628..2463589 - 1962 WP_012311648.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMV91_RS12035 2463662..2464198 - 537 WP_000429154.1 DNA-binding transcriptional regulator SutR -
JMV91_RS12040 2464251..2465171 + 921 Protein_2345 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2465186..2466514 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T290661 WP_000813794.1 NZ_LR890326:c2461084-2460908 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT290661 WP_001270286.1 NZ_LR890326:c2460862-2460446 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References