Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1513176..1513881 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag JMV91_RS07190 Protein ID WP_000539521.1
Coordinates 1513495..1513881 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JMV91_RS07185 Protein ID WP_001280945.1
Coordinates 1513176..1513505 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS07170 1508334..1509245 + 912 WP_001236058.1 glutathione ABC transporter permease GsiD -
JMV91_RS07175 1509422..1511770 + 2349 WP_000950337.1 EAL domain-containing protein -
JMV91_RS07180 1511778..1513106 + 1329 WP_000086869.1 GGDEF domain-containing protein -
JMV91_RS07185 1513176..1513505 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JMV91_RS07190 1513495..1513881 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV91_RS07195 1514107..1515432 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JMV91_RS07200 1515645..1516028 + 384 WP_000497137.1 biofilm formation regulator BssR -
JMV91_RS07205 1516139..1517254 + 1116 WP_000555050.1 aldose sugar dehydrogenase YliI -
JMV91_RS07210 1517251..1517877 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T290655 WP_000539521.1 NZ_LR890326:c1513881-1513495 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT290655 WP_001280945.1 NZ_LR890326:c1513505-1513176 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References