Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1158532..1159150 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JMV91_RS05485 Protein ID WP_001291435.1
Coordinates 1158532..1158750 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JMV91_RS05490 Protein ID WP_000344800.1
Coordinates 1158776..1159150 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS05450 1153822..1154394 + 573 WP_000779831.1 YbaY family lipoprotein -
JMV91_RS05455 1154425..1154736 - 312 WP_000409911.1 MGMT family protein -
JMV91_RS05465 1155115..1155468 + 354 WP_000878140.1 DUF1428 domain-containing protein -
JMV91_RS05470 1155509..1157059 - 1551 WP_012311818.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JMV91_RS05475 1157223..1157693 - 471 WP_000136192.1 YlaC family protein -
JMV91_RS05480 1157809..1158360 - 552 WP_000102561.1 maltose O-acetyltransferase -
JMV91_RS05485 1158532..1158750 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JMV91_RS05490 1158776..1159150 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JMV91_RS05495 1159696..1162845 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
JMV91_RS05500 1162868..1164061 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290654 WP_001291435.1 NZ_LR890326:c1158750-1158532 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT290654 WP_000344800.1 NZ_LR890326:c1159150-1158776 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References