Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 969330..970036 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name ypjF Uniprot ID V0SXW1
Locus tag JMV91_RS04585 Protein ID WP_000854677.1
Coordinates 969668..970036 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID V0SU84
Locus tag JMV91_RS04580 Protein ID WP_000065824.1
Coordinates 969330..969647 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS04555 966421..967598 + 1178 WP_152895938.1 IS3 family transposase -
JMV91_RS04560 967809..968045 + 237 Protein_883 DUF905 domain-containing protein -
JMV91_RS04565 968131..968589 + 459 WP_000211834.1 antirestriction protein -
JMV91_RS04570 968601..969080 + 480 WP_000438147.1 RadC family protein -
JMV91_RS04575 969089..969310 + 222 WP_001220307.1 DUF987 domain-containing protein -
JMV91_RS04580 969330..969647 + 318 WP_000065824.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMV91_RS04585 969668..970036 + 369 WP_000854677.1 TA system toxin CbtA family protein Toxin
JMV91_RS04590 970829..971443 + 615 WP_001019920.1 YagU family protein -
JMV91_RS04595 971692..972021 - 330 WP_001303809.1 YkgJ family cysteine cluster protein -
JMV91_RS04600 972334..973044 - 711 Protein_891 fimbrial chaperone EcpE -
JMV91_RS04605 973013..974656 - 1644 WP_001265639.1 fimbrial adhesin EcpD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC 959630..998367 38737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13687.89 Da        Isoelectric Point: 8.2671

>T290652 WP_000854677.1 NZ_LR890326:969668-970036 [Escherichia coli]
MKTLPATTPQAAKPCLSPVSVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
TSQVQAPYLTTTDILQARKACGLMSRCSYREVSNIVLSRSRL

Download         Length: 369 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11964.46 Da        Isoelectric Point: 6.3163

>AT290652 WP_000065824.1 NZ_LR890326:969330-969647 [Escherichia coli]
MSNITWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAEYRKLDETFPHFISQMESMLTTGEMNPRHAHCVTLYH
DGFTCEADTLGSCGYVYIVVYSTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXW1

Antitoxin

Source ID Structure
AlphaFold DB V0SU84

References