Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 427757..428352 Replicon chromosome
Accession NZ_LR890326
Organism Escherichia coli isolate MINF_1A-sc-2280431

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag JMV91_RS02145 Protein ID WP_000239581.1
Coordinates 428002..428352 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JMV91_RS02140 Protein ID WP_001223213.1
Coordinates 427757..428008 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV91_RS02130 423422..427201 + 3780 WP_000060872.1 autotransporter assembly complex protein TamB -
JMV91_RS02135 427204..427545 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JMV91_RS02140 427757..428008 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JMV91_RS02145 428002..428352 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
JMV91_RS02150 428431..428961 - 531 WP_000055075.1 inorganic diphosphatase -
JMV91_RS02155 429271..430227 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JMV91_RS02160 430360..431862 + 1503 WP_001095664.1 sugar ABC transporter ATP-binding protein -
JMV91_RS02165 431876..432898 + 1023 WP_012311695.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T290650 WP_000239581.1 NZ_LR890326:428002-428352 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT290650 WP_001223213.1 NZ_LR890326:427757-428008 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References