Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 70102..70745 Replicon plasmid 3
Accession NZ_LR890325
Organism Klebsiella pneumoniae isolate INF348-sc-2280170

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JMW45_RS26275 Protein ID WP_048335684.1
Coordinates 70329..70745 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag JMW45_RS26270 Protein ID WP_001261276.1
Coordinates 70102..70332 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW45_RS26250 66225..67007 - 783 WP_048235058.1 site-specific integrase -
JMW45_RS26255 67045..67392 - 348 WP_074405026.1 hypothetical protein -
JMW45_RS26260 67754..68563 - 810 WP_053059919.1 hypothetical protein -
JMW45_RS26265 68560..69480 - 921 WP_201522427.1 hypothetical protein -
JMW45_RS26270 70102..70332 + 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMW45_RS26275 70329..70745 + 417 WP_048335684.1 type II toxin-antitoxin system VapC family toxin Toxin
JMW45_RS26280 70904..71509 - 606 WP_000509966.1 recombinase family protein -
JMW45_RS26285 71604..74501 + 2898 WP_023307208.1 Tn3-like element Tn5403 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..137629 137629


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15079.57 Da        Isoelectric Point: 7.8644

>T290648 WP_048335684.1 NZ_LR890325:70329-70745 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT290648 WP_001261276.1 NZ_LR890325:70102-70332 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References