290646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 69037..69773 Replicon plasmid 2
Accession NZ_LR890324
Organism Klebsiella pneumoniae isolate INF348-sc-2280170

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag JMW45_RS25535 Protein ID WP_004187044.1
Coordinates 69037..69519 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMW45_RS25540 Protein ID WP_003026799.1
Coordinates 69507..69773 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW45_RS25510 65061..65997 - 937 Protein_60 ISNCY family transposase -
JMW45_RS25515 66107..66277 + 171 Protein_61 transposase -
JMW45_RS25520 66275..66382 + 108 Protein_62 IS3 family transposase -
JMW45_RS25525 66616..67320 - 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
JMW45_RS25530 67480..68826 - 1347 WP_077251107.1 ISNCY family transposase -
JMW45_RS25535 69037..69519 - 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
JMW45_RS25540 69507..69773 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMW45_RS25545 69924..70628 + 705 WP_060579418.1 IS6-like element IS26 family transposase -
JMW45_RS25550 70787..73372 - 2586 WP_004187040.1 EAL domain-containing protein -
JMW45_RS25555 73341..73586 - 246 WP_032238678.1 hypothetical protein -
JMW45_RS25560 73644..74624 - 981 Protein_70 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..138469 138469
- inside IScluster/Tn - - 58784..74624 15840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T290646 WP_004187044.1 NZ_LR890324:c69519-69037 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT290646 WP_003026799.1 NZ_LR890324:c69773-69507 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References