Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4596200..4596716 Replicon chromosome
Accession NZ_LR890323
Organism Klebsiella pneumoniae isolate INF348-sc-2280170

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag JMW45_RS22570 Protein ID WP_009309309.1
Coordinates 4596200..4596484 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMW45_RS22575 Protein ID WP_002886901.1
Coordinates 4596474..4596716 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW45_RS22545 4591684..4591992 - 309 WP_020079792.1 PTS sugar transporter subunit IIB -
JMW45_RS22550 4592077..4592250 + 174 WP_032412860.1 hypothetical protein -
JMW45_RS22555 4592253..4592996 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMW45_RS22560 4593353..4595491 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMW45_RS22565 4595732..4596196 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW45_RS22570 4596200..4596484 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW45_RS22575 4596474..4596716 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW45_RS22580 4596794..4598704 - 1911 WP_201522290.1 BglG family transcription antiterminator -
JMW45_RS22585 4598727..4599881 - 1155 WP_023280781.1 lactonase family protein -
JMW45_RS22590 4599948..4600688 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T290643 WP_009309309.1 NZ_LR890323:c4596484-4596200 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290643 WP_002886901.1 NZ_LR890323:c4596716-4596474 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References