Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 728326..729104 Replicon chromosome
Accession NZ_LR890323
Organism Klebsiella pneumoniae isolate INF348-sc-2280170

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag JMW45_RS03670 Protein ID WP_031591140.1
Coordinates 728616..729104 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMW45_RS03665 Protein ID WP_004150912.1
Coordinates 728326..728619 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW45_RS03645 723534..724136 - 603 WP_004174410.1 short chain dehydrogenase -
JMW45_RS03650 724234..725145 + 912 WP_004181308.1 LysR family transcriptional regulator -
JMW45_RS03655 725146..726294 - 1149 WP_004174416.1 PLP-dependent aspartate aminotransferase family protein -
JMW45_RS03660 726305..727681 - 1377 WP_004217775.1 cystathionine beta-synthase -
JMW45_RS03665 728326..728619 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMW45_RS03670 728616..729104 + 489 WP_031591140.1 GNAT family N-acetyltransferase Toxin
JMW45_RS03675 729185..731617 - 2433 Protein_722 hypothetical protein -
JMW45_RS03680 731618..732586 + 969 WP_080465744.1 IS5 family transposase -
JMW45_RS03685 732626..733807 - 1182 Protein_724 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17604.53 Da        Isoelectric Point: 7.7754

>T290634 WP_031591140.1 NZ_LR890323:728616-729104 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCGSDSNVLAYYSLASSAVMTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT290634 WP_004150912.1 NZ_LR890323:728326-728619 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References