Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 657585..658264 Replicon chromosome
Accession NZ_LR890323
Organism Klebsiella pneumoniae isolate INF348-sc-2280170

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag JMW45_RS03300 Protein ID WP_201522333.1
Coordinates 657923..658264 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag JMW45_RS03295 Protein ID WP_201522332.1
Coordinates 657585..657902 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW45_RS03250 652933..653550 + 618 Protein_638 DUF945 domain-containing protein -
JMW45_RS03255 653759..654469 + 711 WP_201522328.1 DeoR family transcriptional regulator -
JMW45_RS03260 654495..655031 + 537 WP_201522329.1 DUF4339 domain-containing protein -
JMW45_RS03265 655073..655510 + 438 WP_023301392.1 hypothetical protein -
JMW45_RS03270 655577..655987 + 411 WP_064411433.1 hypothetical protein -
JMW45_RS03275 656065..656301 + 237 WP_064411434.1 DUF905 domain-containing protein -
JMW45_RS03280 656387..656845 + 459 WP_023301394.1 antirestriction protein -
JMW45_RS03285 656854..657336 + 483 WP_201522330.1 RadC family protein -
JMW45_RS03290 657345..657566 + 222 WP_201522331.1 DUF987 domain-containing protein -
JMW45_RS03295 657585..657902 + 318 WP_201522332.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMW45_RS03300 657923..658264 + 342 WP_201522333.1 TA system toxin CbtA family protein Toxin
JMW45_RS03310 658626..659132 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
JMW45_RS03315 659231..661072 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
JMW45_RS03320 661291..663036 - 1746 WP_201522334.1 DNA primase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 635891..658264 22373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12910.01 Da        Isoelectric Point: 10.3872

>T290633 WP_201522333.1 NZ_LR890323:657923-658264 [Klebsiella pneumoniae]
MKTLSATISRAAKPCLSPVAVWQMLLTRLLEKHYALTLNDTPFGDERVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRKNSVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11889.36 Da        Isoelectric Point: 6.6246

>AT290633 WP_201522332.1 NZ_LR890323:657585-657902 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECRKLDETFPHFISQMESMLTTGELNPRHAHCVTLYH
NGFTCEADTFGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References