290623

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4104318..4105024 Replicon chromosome
Accession NZ_LR890317
Organism Klebsiella pneumoniae isolate INF215-sc-2280087

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag JMX39_RS20280 Protein ID WP_024622903.1
Coordinates 4104656..4105024 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A485WAM6
Locus tag JMX39_RS20275 Protein ID WP_023302278.1
Coordinates 4104318..4104635 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX39_RS20230 4099459..4100283 + 825 WP_023302271.1 DUF945 domain-containing protein -
JMX39_RS20235 4100492..4101202 + 711 WP_023302272.1 DeoR family transcriptional regulator -
JMX39_RS20240 4101228..4101764 + 537 WP_023302273.1 DUF4339 domain-containing protein -
JMX39_RS20245 4101806..4102243 + 438 WP_023301392.1 hypothetical protein -
JMX39_RS20250 4102310..4102720 + 411 WP_023302274.1 hypothetical protein -
JMX39_RS20255 4102798..4103034 + 237 WP_032410024.1 DUF905 domain-containing protein -
JMX39_RS20260 4103121..4103579 + 459 WP_023302275.1 antirestriction protein -
JMX39_RS20265 4103588..4104070 + 483 WP_023302276.1 RadC family protein -
JMX39_RS20270 4104079..4104300 + 222 WP_023302277.1 DUF987 domain-containing protein -
JMX39_RS20275 4104318..4104635 + 318 WP_023302278.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMX39_RS20280 4104656..4105024 + 369 WP_024622903.1 TA system toxin CbtA family protein Toxin
JMX39_RS20285 4105021..4105362 + 342 WP_024622904.1 hypothetical protein -
JMX39_RS20290 4105485..4108130 - 2646 WP_024622905.1 LuxR family transcriptional regulator -
JMX39_RS20295 4108504..4109463 + 960 WP_023302280.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-104)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13651.82 Da        Isoelectric Point: 7.2897

>T290623 WP_024622903.1 NZ_LR890317:4104656-4105024 [Klebsiella pneumoniae]
MKNLPATISQAAKPCLSPVAVWQMLLTHLLEQHYGLMLSDTPFSDEAVIQEHIDAGITLANAVNFLVEKYELVRIDRCGF
SSQVQAPYLTATDILHARKACGLMSRYSYREVSNIVLSRSRI

Download         Length: 369 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11860.67 Da        Isoelectric Point: 6.4629

>AT290623 WP_023302278.1 NZ_LR890317:4104318-4104635 [Klebsiella pneumoniae]
MSNPTWGLLRDITPCLGARLVQEGNRLYYLVDRASITGKFSDAEILKLDVVFPHFISQMESMLTIGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYLTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A485WAM6

References