Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 31406..32316 Replicon plasmid 2
Accession NZ_LR890313
Organism Klebsiella oxytoca isolate MSB1_10D-sc-2280340

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag JMX52_RS27330 Protein ID WP_004026354.1
Coordinates 31846..32316 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag JMX52_RS27325 Protein ID WP_004026357.1
Coordinates 31406..31849 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX52_RS27305 26687..27394 + 708 WP_072198721.1 hypothetical protein -
JMX52_RS27310 27399..28430 + 1032 WP_170918258.1 CRISPR-associated protein Csf2 -
JMX52_RS27315 29612..30034 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
JMX52_RS27320 30034..31305 + 1272 WP_201621187.1 translesion error-prone DNA polymerase V subunit UmuC -
JMX52_RS27325 31406..31849 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
JMX52_RS27330 31846..32316 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
JMX52_RS27335 32771..32959 - 189 WP_024198076.1 hypothetical protein -
JMX52_RS27340 33571..33831 - 261 WP_201621188.1 hypothetical protein -
JMX52_RS27345 34554..34712 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
JMX52_RS27350 35317..36291 + 975 WP_032719543.1 hypothetical protein -
JMX52_RS27355 36488..36865 - 378 WP_032719541.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..201460 201460


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T290612 WP_004026354.1 NZ_LR890313:31846-32316 [Klebsiella oxytoca]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT290612 WP_004026357.1 NZ_LR890313:31406-31849 [Klebsiella oxytoca]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References