Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4375027..4375646 Replicon chromosome
Accession NZ_LR890312
Organism Klebsiella oxytoca isolate MSB1_10D-sc-2280340

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag JMX52_RS20465 Protein ID WP_004099646.1
Coordinates 4375428..4375646 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag JMX52_RS20460 Protein ID WP_004099648.1
Coordinates 4375027..4375401 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX52_RS20450 4370183..4371376 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMX52_RS20455 4371399..4374545 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit -
JMX52_RS20460 4375027..4375401 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
JMX52_RS20465 4375428..4375646 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
JMX52_RS20470 4375807..4376373 + 567 WP_023320460.1 maltose O-acetyltransferase -
JMX52_RS20475 4376510..4376980 + 471 WP_004111038.1 YlaC family protein -
JMX52_RS20480 4376955..4378409 - 1455 WP_023320459.1 PLP-dependent aminotransferase family protein -
JMX52_RS20485 4378511..4379209 + 699 WP_004099639.1 GNAT family N-acetyltransferase -
JMX52_RS20490 4379206..4379346 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
JMX52_RS20495 4379346..4379609 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T290609 WP_004099646.1 NZ_LR890312:4375428-4375646 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT290609 WP_004099648.1 NZ_LR890312:4375027-4375401 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References