Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4664902..4665418 Replicon chromosome
Accession NZ_LR890307
Organism Klebsiella pneumoniae isolate INF188-sc-2280054

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JMW12_RS22870 Protein ID WP_002886902.1
Coordinates 4664902..4665186 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMW12_RS22875 Protein ID WP_002886901.1
Coordinates 4665176..4665418 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW12_RS22845 4660318..4660626 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMW12_RS22850 4660711..4660884 + 174 WP_032410138.1 hypothetical protein -
JMW12_RS22855 4660887..4661630 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
JMW12_RS22860 4661987..4664125 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMW12_RS22865 4664434..4664898 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW12_RS22870 4664902..4665186 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW12_RS22875 4665176..4665418 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW12_RS22880 4665496..4667406 - 1911 WP_009486549.1 BglG family transcription antiterminator -
JMW12_RS22885 4667429..4668583 - 1155 WP_085808042.1 lactonase family protein -
JMW12_RS22890 4668650..4669390 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T290598 WP_002886902.1 NZ_LR890307:c4665186-4664902 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290598 WP_002886901.1 NZ_LR890307:c4665418-4665176 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References