Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3492232..3492844 Replicon chromosome
Accession NZ_LR890299
Organism Escherichia coli isolate MSB1_3B-sc-2280406

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag JM188_RS16555 Protein ID WP_000833473.1
Coordinates 3492232..3492417 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag JM188_RS16560 Protein ID WP_000499744.1
Coordinates 3492434..3492844 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM188_RS16545 3489073..3490224 + 1152 WP_000741501.1 L-threonine dehydrogenase -
JM188_RS16550 3490425..3491963 + 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
JM188_RS16555 3492232..3492417 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
JM188_RS16560 3492434..3492844 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JM188_RS16565 3492916..3494880 - 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
JM188_RS16570 3494891..3496291 - 1401 WP_000204811.1 MFS transporter -
JM188_RS16575 3496517..3497332 + 816 WP_000891823.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T290564 WP_000833473.1 NZ_LR890299:3492232-3492417 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT290564 WP_000499744.1 NZ_LR890299:3492434-3492844 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References