Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1928189..1928807 Replicon chromosome
Accession NZ_LR890299
Organism Escherichia coli isolate MSB1_3B-sc-2280406

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JM188_RS09370 Protein ID WP_001291435.1
Coordinates 1928589..1928807 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JM188_RS09365 Protein ID WP_000344800.1
Coordinates 1928189..1928563 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM188_RS09355 1923278..1924471 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JM188_RS09360 1924494..1927643 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
JM188_RS09365 1928189..1928563 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JM188_RS09370 1928589..1928807 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JM188_RS09375 1928979..1929530 + 552 WP_000102564.1 maltose O-acetyltransferase -
JM188_RS09380 1929646..1930116 + 471 WP_000136192.1 YlaC family protein -
JM188_RS09385 1930280..1931830 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JM188_RS09390 1931872..1932225 - 354 WP_001550741.1 DUF1428 family protein -
JM188_RS09400 1932604..1932915 + 312 WP_000409911.1 MGMT family protein -
JM188_RS09405 1932946..1933518 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T290555 WP_001291435.1 NZ_LR890299:1928589-1928807 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT290555 WP_000344800.1 NZ_LR890299:1928189-1928563 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References