Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 785124..785762 Replicon chromosome
Accession NZ_LR890299
Organism Escherichia coli isolate MSB1_3B-sc-2280406

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag JM188_RS03740 Protein ID WP_000813795.1
Coordinates 785586..785762 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JM188_RS03735 Protein ID WP_076797675.1
Coordinates 785124..785540 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM188_RS03715 780276..781217 - 942 WP_001251315.1 ABC transporter permease -
JM188_RS03720 781218..782231 - 1014 WP_001551095.1 ABC transporter ATP-binding protein -
JM188_RS03725 782249..783394 - 1146 WP_001551094.1 ABC transporter substrate-binding protein -
JM188_RS03730 783639..785045 - 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
JM188_RS03735 785124..785540 - 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JM188_RS03740 785586..785762 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JM188_RS03745 785984..786214 + 231 WP_023910283.1 YncJ family protein -
JM188_RS03750 786306..788267 - 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JM188_RS03755 788340..788876 - 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
JM188_RS03760 788929..790140 + 1212 WP_071591517.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T290552 WP_000813795.1 NZ_LR890299:c785762-785586 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT290552 WP_076797675.1 NZ_LR890299:c785540-785124 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References