Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 79584..80320 Replicon plasmid 2
Accession NZ_LR890292
Organism Klebsiella pneumoniae strain KSB1_1B

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag JMW65_RS26025 Protein ID WP_004187044.1
Coordinates 79838..80320 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMW65_RS26020 Protein ID WP_003026799.1
Coordinates 79584..79850 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW65_RS26000 74733..75713 + 981 Protein_76 IS5 family transposase -
JMW65_RS26005 75771..76016 + 246 WP_032238678.1 hypothetical protein -
JMW65_RS26010 75985..78570 + 2586 WP_004187040.1 EAL domain-containing protein -
JMW65_RS26015 78729..79433 - 705 WP_060579418.1 IS6-like element IS26 family transposase -
JMW65_RS26020 79584..79850 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMW65_RS26025 79838..80320 + 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
JMW65_RS26030 80478..82010 - 1533 WP_015065592.1 IS3-like element ISKpn38 family transposase -
JMW65_RS26035 82133..83479 + 1347 WP_077251107.1 ISNCY family transposase -
JMW65_RS26040 83639..84343 + 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
JMW65_RS26045 84577..84684 - 108 Protein_85 IS3 family transposase -
JMW65_RS26050 84682..84852 - 171 Protein_86 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..133165 133165
- inside IScluster/Tn - - 74733..85919 11186


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T290545 WP_004187044.1 NZ_LR890292:79838-80320 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT290545 WP_003026799.1 NZ_LR890292:79584-79850 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References