Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 66167..66689 Replicon plasmid 2
Accession NZ_LR890292
Organism Klebsiella pneumoniae strain KSB1_1B

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag JMW65_RS25935 Protein ID WP_004187019.1
Coordinates 66167..66451 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag JMW65_RS25940 Protein ID WP_004187025.1
Coordinates 66441..66689 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW65_RS25910 61386..61850 - 465 WP_004187010.1 hypothetical protein -
JMW65_RS25915 63393..63917 + 525 Protein_59 hypothetical protein -
JMW65_RS25920 63934..64417 + 484 Protein_60 hypothetical protein -
JMW65_RS25925 64415..64714 + 300 Protein_61 conjugal transfer protein TraH -
JMW65_RS25930 64796..66151 + 1356 WP_004187017.1 ISNCY family transposase -
JMW65_RS25935 66167..66451 - 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW65_RS25940 66441..66689 - 249 WP_004187025.1 plasmid stabilization protein Antitoxin
JMW65_RS25945 66979..67403 - 425 Protein_65 IS1 family transposase -
JMW65_RS25950 67591..67707 - 117 Protein_66 transposase domain-containing protein -
JMW65_RS25955 67652..67915 - 264 WP_004187027.1 transposase -
JMW65_RS25960 67930..68193 + 264 WP_004118208.1 hypothetical protein -
JMW65_RS25965 68437..68718 + 282 WP_013307885.1 helix-turn-helix domain-containing protein -
JMW65_RS25970 68753..69322 + 570 WP_004152117.1 small heat shock protein sHSP20 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..133165 133165
- flank IS/Tn - - 67128..67352 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T290544 WP_004187019.1 NZ_LR890292:c66451-66167 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT290544 WP_004187025.1 NZ_LR890292:c66689-66441 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References