290543

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5174226..5174851 Replicon chromosome
Accession NZ_LR890291
Organism Klebsiella pneumoniae strain KSB1_1B

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMW65_RS25255 Protein ID WP_094645114.1
Coordinates 5174226..5174609 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMW65_RS25260 Protein ID WP_004150355.1
Coordinates 5174609..5174851 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW65_RS25240 5171592..5172494 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JMW65_RS25245 5172491..5173126 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMW65_RS25250 5173123..5174052 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JMW65_RS25255 5174226..5174609 - 384 WP_094645114.1 type II toxin-antitoxin system VapC family toxin Toxin
JMW65_RS25260 5174609..5174851 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMW65_RS25265 5175056..5175973 + 918 WP_088497967.1 alpha/beta hydrolase -
JMW65_RS25270 5175987..5176928 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMW65_RS25275 5176973..5177410 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMW65_RS25280 5177407..5178267 - 861 WP_002882807.1 virulence factor BrkB family protein -
JMW65_RS25285 5178261..5178860 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14324.57 Da        Isoelectric Point: 6.7186

>T290543 WP_094645114.1 NZ_LR890291:c5174609-5174226 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGCREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT290543 WP_004150355.1 NZ_LR890291:c5174851-5174609 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References