Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4696380..4696896 Replicon chromosome
Accession NZ_LR890291
Organism Klebsiella pneumoniae strain KSB1_1B

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JMW65_RS22975 Protein ID WP_094645165.1
Coordinates 4696380..4696664 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMW65_RS22980 Protein ID WP_002886901.1
Coordinates 4696654..4696896 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW65_RS22950 4691776..4692084 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMW65_RS22955 4692169..4692342 + 174 WP_032408826.1 hypothetical protein -
JMW65_RS22960 4692345..4693088 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMW65_RS22965 4693445..4695583 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMW65_RS22970 4695912..4696376 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW65_RS22975 4696380..4696664 - 285 WP_094645165.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW65_RS22980 4696654..4696896 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW65_RS22985 4696974..4698884 - 1911 WP_009486549.1 BglG family transcription antiterminator -
JMW65_RS22990 4698907..4700061 - 1155 WP_004178372.1 lactonase family protein -
JMW65_RS22995 4700128..4700868 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11069.93 Da        Isoelectric Point: 10.4962

>T290541 WP_094645165.1 NZ_LR890291:c4696664-4696380 [Klebsiella pneumoniae]
MTYELEFDPRAWRGWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290541 WP_002886901.1 NZ_LR890291:c4696896-4696654 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References