Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2092522..2093036 Replicon chromosome
Accession NC_020529
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag SAI1T1_RS10485 Protein ID WP_000581792.1
Coordinates 2092522..2092731 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag SAI1T1_RS10490 Protein ID WP_000138932.1
Coordinates 2092743..2093036 (-) Length 98 a.a.

Genomic Context

SAI1T1_RS10475SAI1T1_RS10495SAI1T1_RS10500SAI1T1_RS10465SAI1T1_RS10470SAI1T1_RS14920SAI1T1_RS10485SAI1T1_RS10490SAI1T1_RS10510SAI1T1_RS10515
Location: 2090791..2091993 (1203 bp)
Type: Others
Protein ID: WP_001109939.1
Location: 2093202..2094686 (1485 bp)
Type: Others
Protein ID: WP_000571549.1
Location: 2094714..2095361 (648 bp)
Type: Others
Protein ID: WP_001187630.1
Location: 2088030..2089388 (1359 bp)
Type: Others
Protein ID: WP_000611464.1
Location: 2089403..2090473 (1071 bp)
Type: Others
Protein ID: WP_000159631.1
Location: 2092257..2092394 (138 bp)
Type: Others
Protein ID: WP_000828354.1
Location: 2092522..2092731 (210 bp)
Type: Toxin
Protein ID: WP_000581792.1
Location: 2092743..2093036 (294 bp)
Type: Antitoxin
Protein ID: WP_000138932.1
Location: 2096174..2097046 (873 bp)
Type: Others
Protein ID: WP_000725802.1
Location: 2097132..2097773 (642 bp)
Type: Others
Protein ID: WP_000483153.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SAI1T1_RS104652088030..2089388-1359WP_000611464.1UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase-
SAI1T1_RS104702089403..2090473-1071WP_000159631.1D-alanine--D-alanine ligase-
SAI1T1_RS104752090791..2091993+1203WP_001109939.1rod shape-determining protein RodA-
SAI1T1_RS149202092257..2092394-138WP_000828354.1hypothetical protein-
SAI1T1_RS104852092522..2092731-210WP_000581792.1heavy-metal-associated domain-containing proteinToxin
SAI1T1_RS104902092743..2093036-294WP_000138932.1copper-sensing transcriptional repressor CsoRAntitoxin
SAI1T1_RS104952093202..2094686+1485WP_000571549.1cardiolipin synthase-
SAI1T1_RS105002094714..2095361+648WP_001187630.1HD domain-containing protein-
SAI1T1_RS105102096174..2097046-873WP_000725802.1membrane protein insertase YidC-
SAI1T1_RS105152097132..2097773-642WP_000483153.1thiamine phosphate synthase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T29054 WP_000581792.1 NC_020529:c2092731-2092522 [Staphylococcus aureus subsp. aureus ST228]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T29054 NC_020529:c2092731-2092522 [Staphylococcus aureus subsp. aureus ST228]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT29054 WP_000138932.1 NC_020529:c2093036-2092743 [Staphylococcus aureus subsp. aureus ST228]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT29054 NC_020529:c2093036-2092743 [Staphylococcus aureus subsp. aureus ST228]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6FF1

Antitoxin

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Source
ID
Structure
AlphaFold DBW8UW13

References